RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-27a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Masson's trichrome staining; Dual-luciferase reporter assay; Chromatin immunoprecipitation assay etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA-27a-3p Is a Negative Regulator of Lung Fibrosis by Targeting Myofibroblast Differentiation
Year
2016
Function
"MiR-27a-3p is induced by TGF-B1 in human lung fibroblasts and in fibroblasts isolated from fibrotic mouse lungs, whereas both basal and TGF-B1-induced expression of miR-27a-3p are reduced in lung fibroblasts from patients with IPF compared with that from normal control subjects. Mechanically, miR-27a-3p inhibits the profibrotic phenotypes of myofibroblasts through directly targeting a-SMA and the Smad transcriptional factors, smad2 and smad4."